Dr. Liyun (Leann) Wang

Department of Mechanical Engineering
University of Delaware
126 Spencer Lab
Newark, DE 19716

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Executive Summary

Dr. Liyun Wang is an associate professor of mechanical engineering at the University of Delaware. She received the B.S. degree in mechanical engineering and the M.S. degree in biomedical engineering from the University of Science and Technology of China (Hefei), and the Ph.D. in mechanical/biomedical engineering from the City University of New York. She conducted postdoctoral research in orthopedics at the Mount Sinai School of Medicine before joining the University of Delaware in 2005. She is the recipient of the Alice L Jee Young Investigator Award (2007). Dr. Wang's research interests are bone and cartilage biomechanics, bioimaging, and mathematical modeling. She is interested in how mechanical loading influences cell and tissue functions and responses. The ultimate goals of her studies on load-induced solute transport around bone cells and cross-talk between bone and cartilage in the joint are i) to elucidate the cellular and molecular mechanisms underlying osteoporosis and osteoarthritis; and ii) to develop more effective treatments.

Key Publications

Wang, L., Wang, Y., Han, Y., Henderson, S.C., Majeska, R.J., Weinbaum, S., and Schaffler, M.B. (2005) In Situ Measurement of Solute Transport in the Bone Lacunar-Canalicular System. Proc. Natl. Acad. Sci. 102, 11911-11916.

Zhou, X., Novotny, J.E., and Wang, L. (2008) Modeling Fluorescence Recovery After Photobleaching in Loaded Bone: Potential Applications in Measuring Fluid and Solute Transport in the Osteocytic Lacunar-Canalicular System. Ann Biomed Eng, 36:1961-77.

Pan, J., Zhou, X., Li, W., Novotney, J.E., Doty, S.B., and Wang, L. (2009) In Situ measurement of transport between subchondral bone and articular cartilage. J Orthop Res, 27:1347-52.

Li, W., You, L., Schaffler, M.B., and Wang, L. (2009) The dependency of solute diffusion on molecular weight and shape in intact bone. Bone, 45: 1017-1023.

Price, C., Zhou, X., Li, W., Wang, L. (2011) Real-time measurement of solute convection within the lacunar-canalicular system of mechanically loaded bone: direct evidence of load-induced fluid flow. J Bone Miner Res, 26:277-85.

Research Areas

Biomedical Engineering
Mechanobiology of skeletal tissues, bioimaging, mathematical modeling, porous media

Biomechanics of bone and cartilage, advanced bioimaging, mathematical/computatinal modeling

Life & Health Sciences
Osteoporosis and osteoarthritis, mechanobiology

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